Biográfia:

James 1954. Október 26.-án Cleveland-ben, Ohio államban született, az USA-ban. Édesapja, James Pickens, nem örült annak, hogy fia a színész szakmát választotta, de James ennek ellenére kitartott álláspontja mellett. 1987-ben kezdte a szakmát, ám leginkább csak az X-aktákból ismerhetjük őt. 2005-től pedig a Grace Klinika góréjaként is.

Filmográfia:

Curb Your Enthusiasm: The Ski Lift (2005) The Smoking Jacket (2005)

Venom (2005) 

Grace Klinika (Grey's Anatomy) (2005 - ????)

Jack & Bobby: Pilot (2004)

The West Wing: Full Disclosure (2004)

Line of Fire:The Senator (2004) 

The Lyon's Den (2003)

Miami Helyszínelők (CSI: Miami) : Body Count (2003)

White Rush (2003)

Six Feet Under: Everyone Leaves (2003)  The Liar and the Whore (2002) 

Becker: But I've Got Friends I Haven't Used Yet (2003) Blind Injustice (2002)

MDs: Cruel and Unusual (2002)

Crossing Jordan: Bombs Away (2002)

Strong Medicine: Outcomes (2002)

X-akták (The X Files) (1998-2002)

Philly: Thanks for the Mammaries (2002)  San Diego Padre (2002) Lies of Minelli (2002) Live and Leg Die (2001) Blown Away (2001)

Home Room (2002)

Semper Fi (2001)

Traffic (2000) 

The Practice: Friends and Ex-Lovers (2000) Black Widows (2000)  Checkmates (2000)  Loser's Keepers (1999) End Games (1999)

Family Law: Family Values (2000) 

The District: The Real Terrorist (2000)

Daddio:The Premium Also Rises (2000)

City of Angels: Deliver the Male (2000)  Assume the Position (2000) The Prince and the Porker (2000)

NYPD Blue: Little Abner (2000) Jackass (2000) Along Came Jones (2000)  Personal Foul (1993)

Any Day Now: Pay Your Dues (2000) A Parent's Job (1999)  Huh? (1998)

Liberty Heights (1999)

JAG - Becsületbeli ügyek (JAG) :Rogue (1999) 

A Slight Case of Murder (1999)

Vengeance Unlimited: Friends (1999)

Little Girl Fly Away (1998) 

How Stella Got Her Groove Back (1998)

Bulworth (1998)

Seinfeld: The Finale: Part 1 (1998) 

Brooklyn South: Skel in a Cell (1998)Violet Inviolate (1998) Touched by a Checkered Cab (1997)  Pilot (1997) 

The Pretender: Crash (1998)

Sphere (1998)

Rocket Man (1997)

Walker, a texasi kopó (Walker, Texas Ranger) :The Fighting McLains (1997)

Pacific Palisades: Past & Present Danger (1997)

Something So Right: Something About How Jack and Carly Met (1997) Something About Reverse Psychology (1997) Something About Schmoozing (1996)  Something About Seared Ahi (1996) Something About Jack's Ex (1996)

Gridlock'd (1997) 

Dangerous Minds: Moonstruck (1996)

Ghosts of Mississippi (1996)

The Uninvited (1996)

Sleepers (1996)

Roseanne: Honor Thy Mother (1996) Construction Junction (1996) Out of the Past (1996) My Name Is Bev (1995)  White Men Can't Kiss (1994) 

Power 98 (1996)

The Lazarus Man: The Conspirator (1996)

In the House: My Crazy Valentine (1996)

Bloodhounds (1996)

Nixon (1995)

Touched by an Angel: The Driver (1995)

Dead Presidents (1995)

Sharon's Secret (1995)

Trial by Fire (1995) 

Lily in Winter (1994) 

A Child's Cry for Help (1994)

Me and the Boys: Black Dads Can't Jump (1994)

Sodbusters (1994) (TV) 

Jimmy Hollywood (1994)

Coach: Blue Chip Blues (1994)

Hostile Intentions (1994)

Menace II Society (1993)

Gyilkos sorok (Murder, She Wrote): The Survivor (1993)

Boiling Point (1993/I)

Doogie Howser, M.D.: Roommate with a View (1992)

Trespass (1992)

L.A. Law: Zo Long (1992)

Exclusive (1992)

Parker Lewis Can't Lose: Hungry Heart (1992)

Blossom: The Letter (1992)

Beverly Hills, 90210: Play It Again, David (1991)  Anaconda (1991)

Hotshot (1987)